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Details on Person Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3)

Class:IdBlackBoxEvent:9909374
_displayNamePhosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3)
_doReleaseTRUE
_timestamp2025-02-18 21:06:24
authored[InstanceEdit:9909367] May, Bruce, 2024-05-11
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:9909380] May, Bruce, 2024-05-13
edited[InstanceEdit:9909367] May, Bruce, 2024-05-11
inferredFrom
input[EntityWithAccessionedSequence:9909379] PER3 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimericFALSE
literatureReference[LiteratureReference:9929328] Multiple circadian transcriptional elements cooperatively regulate cell-autonomous transcriptional oscillation of Period3, a mammalian clock gene
[LiteratureReference:9930029] Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
modified[InstanceEdit:9923060] May, Bruce, 2024-09-29
[InstanceEdit:9925663] May, Bruce, 2024-10-21
[InstanceEdit:9926648] May, Bruce, 2024-11-01
[InstanceEdit:9929342] May, Bruce, 2024-11-24
[InstanceEdit:9930033] May, Bruce, 2024-11-30
[InstanceEdit:9932107] May, Bruce, 2024-12-17
[InstanceEdit:9935064] May, Bruce, 2025-01-12
[InstanceEdit:9936399] May, Bruce, 2025-01-22
[InstanceEdit:9936865] May, Bruce, 2025-01-27
[InstanceEdit:9938391] May, Bruce, 2025-02-14
[InstanceEdit:9938517] May, Bruce, 2025-02-17
[InstanceEdit:9938697] May, Bruce, 2025-02-18
namePhosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3)
output[EntityWithAccessionedSequence:400323] PER3 [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveGeneExpressionRegulation:9909366] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9925653] Positive gene expression regulation by 'TFEB [nucleoplasm]'
regulationReference[RegulationReference:9925651] Positive gene expression regulation by 'TFEB [nucleoplasm]' TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1
releaseDate2025-03-26
reviewed[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14
[InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9909424] R-HSA-9909374.1
structureModified[InstanceEdit:9925663] May, Bruce, 2024-10-21
summation[Summation:9929332] Phosphorylated BMAL1:CLOCK bound to the promoter of PER3 act...
(hasEvent)[Pathway:9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9909392] Formation of CRY:PER:Kinase complex [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3) (9909374)
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