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Details on Person CSNK1E,CSNK1D phosphorylate CRY and PER proteins

Class:Id	Reaction:9909369
_displayName	CSNK1E,CSNK1D phosphorylate CRY and PER proteins
_doRelease	TRUE
_timestamp	2025-02-26 18:01:41
authored	[InstanceEdit:9909367] May, Bruce, 2024-05-11
catalystActivity	[CatalystActivity:9933502] protein serine/threonine kinase activity of CRY1:CRY2:PER1:p-S396-PER2:PER3:CSNK1E,CSNK1D [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9909380] May, Bruce, 2024-05-13
edited	[InstanceEdit:9909367] May, Bruce, 2024-05-11
inferredFrom	[Reaction:9909394] Csnk1e,Csnk1d phosphorylate Cry and Per proteins [Mus musculus]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9909381] CRY1:CRY2:PER1:p-S396-PER2:PER3:CSNK1E,CSNK1D [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
literatureReference	[LiteratureReference:400293] Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts [LiteratureReference:508355] CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock [LiteratureReference:508347] An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome [LiteratureReference:508333] Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2 [LiteratureReference:508733] Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome [LiteratureReference:508746] Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon [LiteratureReference:9920648] CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch
modified	[InstanceEdit:9911591] May, Bruce, 2024-06-01 [InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9923960] May, Bruce, 2024-10-05 [InstanceEdit:9925663] May, Bruce, 2024-10-21 [InstanceEdit:9931013] May, Bruce, 2024-12-09 [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9933511] May, Bruce, 2024-12-31 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9939392] May, Bruce, 2025-02-26
name	CSNK1E,CSNK1D phosphorylate CRY and PER proteins
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:9909377] p-S-CRY1:p-S-CRY2:p-S-PER1:p-7S-PER2:p-S-PER3:CSNK1E,CSNK1D [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9909392] Formation of CRY:PER:Kinase complex [Homo sapiens] [BlackBoxEvent:9922989] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Cryptochrome-1 (CRY1) [Homo sapiens] [BlackBoxEvent:9925647] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2) [Homo sapiens] [BlackBoxEvent:9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) [Homo sapiens] [Reaction:9920673] CDK5 phosphorylates PER2 on serine-396 [Homo sapiens] [BlackBoxEvent:9909374] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:5656529] Negative regulation by 'PP1 catalytic subunit [cytosol]' [PositiveRegulation:9925658] Positive regulation by 'Casein kinase II [cytosol]'
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909411] R-HSA-9909369.1
structureModified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9923960] May, Bruce, 2024-10-05 [InstanceEdit:9925663] May, Bruce, 2024-10-21 [InstanceEdit:9933511] May, Bruce, 2024-12-31
summation	[Summation:9930072] In the cytosol the kinases casein kinase I delta (CSNK1D) an...
(hasEvent)	[Pathway:9931530] Phosphorylation and nuclear translocation of the CRY:PER:kinase complex [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9909565] p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus [Homo sapiens] [Reaction:9932506] BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein [Homo sapiens] [Reaction:9932869] FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2 [Homo sapiens]
(replacementInstances)	[_Deleted:9938768] Deletion of instance: 400382
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No pathways have been reviewed or authored by CSNK1E,CSNK1D phosphorylate CRY and PER proteins (9909369)