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Details on Person UniProt:P40306 PSMB10
| Class:Id | ReferenceGeneProduct:99090 |
|---|---|
| _chainChangeLog | propeptide:1-39 added on Fri February 6 2015;chain:40-273 added on Fri February 6 2015 |
| _displayName | UniProt:P40306 PSMB10 |
| _timestamp | 2025-02-21 20:02:52 |
| chain | propeptide:1-39 chain:40-273 |
| checksum | D6728E50513A45B9 |
| comment | FUNCTION The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.CATALYTIC ACTIVITY Cleavage of peptide bonds with very broad specificity.SUBUNIT The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.SUBUNIT (Microbial infection) Interacts with HIV-1 TAT protein.INTERACTION Highly expressed in immature dendritic cells (at protein level).INDUCTION Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.PTM Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase T1B family. |
| description | recommendedName: Proteasome subunit beta type-10 ecNumber: 3.4.25.1 alternativeName: Low molecular mass protein 10 alternativeName: Macropain subunit MECl-1 alternativeName: Multicatalytic endopeptidase complex subunit MECl-1 alternativeName: Proteasome MECl-1 alternativeName: fullName evidence="15"Proteasome subunit beta-2i |
| geneName | PSMB10 LMP10 MECL1 |
| identifier | P40306 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Disease variant Host-virus interaction Hydrolase Nucleus Phosphoprotein Protease Proteasome Proteomics identification Reference proteome Threonine protease Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PSMB10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962140] ENSEMBL:ENSG00000205220 PSMB10 [Homo sapiens] |
| secondaryIdentifier | PSB10_HUMAN B2R5J4 Q5U098 |
| sequenceLength | 273 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68741] PSMB10 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174349] PSMB10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9908123] pro-PSMB10 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9908142] PSMB10(1-39) [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P40306 PSMB10 (99090)
