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Details on Person The outer ring of 20S core particle (20S CP) of 26S proteaso...
| Class:Id | Summation:9907910 |
|---|---|
| _displayName | The outer ring of 20S core particle (20S CP) of 26S proteaso... |
| _timestamp | 2024-04-23 15:56:16 |
| created | [InstanceEdit:9907909] Orlic-Milacic, Marija, 2024-04-18 |
| literatureReference | [LiteratureReference:9907904] Molecular architecture and assembly of the eukaryotic proteasome |
| modified | [InstanceEdit:9908049] Orlic-Milacic, Marija, 2024-04-18 [InstanceEdit:9908229] Orlic-Milacic, Marija, 2024-04-19 [InstanceEdit:9908230] Orlic-Milacic, Marija, 2024-04-19 [InstanceEdit:9908463] Orlic-Milacic, Marija, 2024-04-22 [InstanceEdit:9908893] Orlic-Milacic, Marija, 2024-04-23 |
| text | The outer ring of 20S core particle (20S CP) of 26S proteasome consist of seven different alpha subunits (alpha1-7, PSMA1-7 officially in humans, where alpha-1 corresponds to PSMA6, alpha-2 to PSMA2, alpha-3 to PSMA4, alpha-4 to PSMA7, alpha-5 to PSMA5, alpha-6 to PSMA1, and alpha-7 to PSMA3) (reviewed in Tomko and Hochstrasser 2013). The PSMA5 (alpha-5) subunit is pre-bound to the proteasome chaperone dimer PSMG3:PSMG4 (Satoh et al. 2019), and PSMG3:PSMG4 is needed for efficient and accurate outer ring assembly (Hirano et al. 2006). In human embryonic kidney cell line 293 (HEK293), the knockdown of PSMG3 increases the level of free forms of alpha subunits (Hirano et al. 2006). |
| (summation) | [Reaction:9907912] Formation of the outer ring of the 20S core particle [Homo sapiens] |
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No pathways have been reviewed or authored by The outer ring of 20S core particle (20S CP) of 26S proteaso... (9907910)
