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Details on Person CACNA2D1, the regulatory subunit of voltage-gated calcium ch...
| Class:Id | Summation:9907459 |
|---|---|
| _displayName | CACNA2D1, the regulatory subunit of voltage-gated calcium ch... |
| _timestamp | 2024-10-07 08:05:31 |
| created | [InstanceEdit:9907471] May, Bruce, 2024-04-10 |
| literatureReference | [LiteratureReference:9923994] Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix |
| modified | [InstanceEdit:9909064] May, Bruce, 2024-04-25 [InstanceEdit:9924062] May, Bruce, 2024-10-06 [InstanceEdit:9924074] May, Bruce, 2024-10-07 |
| text | CACNA2D1, the regulatory subunit of voltage-gated calcium channels (VGCCs), normally associates with L-type VGCCs, however, in osteocytes CACNA2D1 associates with the T-type VGCC CACNA1H (CaV3.2) and is required for the opening of CACNA1H in response to membrane stretch (inferred from mouse homologs). CACNA2D1 also directly interacts with perlecan (heparan sulfated HSPG2) (inferred from mouse homologs), a component of the extracellular matrix with size and elesticity that are suitable for tethering in the lacunar canalicular system (Wijeratne et al. 2016). Mechanical force on perlecan thus appears to regulate the calcium permeability of the CaV3.2 channels. The opening of CACNA1H channels is required for the release of ATP by osteocytes in response to membrane stretch (inferred from mouse cells). Loss of CACNA2D1 causes loss of skeletal strength in males and females and loss of response to skeletal loading in males (inferred from mice). |
| (summation) | [Reaction:9905934] CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol [Homo sapiens] |
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No pathways have been reviewed or authored by CACNA2D1, the regulatory subunit of voltage-gated calcium ch... (9907459)
