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Details on Person Treatment of mouse white preadipocyte cell line 3T3-L1 with ...
| Class:Id | Summation:9907272 |
|---|---|
| _displayName | Treatment of mouse white preadipocyte cell line 3T3-L1 with ... |
| _timestamp | 2025-11-04 05:14:30 |
| created | [InstanceEdit:9907271] Orlic-Milacic, Marija, 2024-04-05 |
| modified | [InstanceEdit:9907518] Orlic-Milacic, Marija, 2024-04-11 [InstanceEdit:9971050] Orlic-Milacic, Marija, 2025-11-04 |
| text | Treatment of mouse white preadipocyte cell line 3T3-L1 with PPARG agonists results in increased Plin2 mRNA levels (Bhalla et al. 2011). Expression of the Plin2 gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information). In a mouse model of hepatic steatosis, expression of the Plin2 gene is directly stimulated by Pparg2 and the Mll4 complex but negatively regulated by imatinib, an Abl1 kinase inhibitor that disrupts Abl1-mediated association between Pparg2 and the Mll4 complex (Kim et al. 2016). |
| (summation) | [BlackBoxEvent:9907270] Plin2 gene expression is positively regulated by Pparg:Rxra and Mll4,(Mll3) complex [Mus musculus] |
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No pathways have been reviewed or authored by Treatment of mouse white preadipocyte cell line 3T3-L1 with ... (9907272)
