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Details on Person Angptl4 gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex

Class:IdBlackBoxEvent:9907162
_displayNameAngptl4 gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex
_doReleaseTRUE
_timestamp2025-11-04 02:17:42
authored[InstanceEdit:9907161] Orlic-Milacic, Marija, 2024-04-04
compartment[Compartment:7660] nucleoplasm
[Compartment:984] extracellular region
created[InstanceEdit:9907161] Orlic-Milacic, Marija, 2024-04-04
edited[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
input[EntityWithAccessionedSequence:9866344] Angptl4 gene [nucleoplasm] [Mus musculus]
internalReviewed[InstanceEdit:9918118] May, Bruce, 2024-08-14
[InstanceEdit:9927587] May, Bruce, 2024-03-08
[InstanceEdit:9928383] Matthews, Lisa, 2024-11-15
isChimericFALSE
literatureReference[LiteratureReference:9858073] H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
[LiteratureReference:9859554] Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation
[LiteratureReference:9859556] Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production
[LiteratureReference:9859565] Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism
[LiteratureReference:9859578] Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
[LiteratureReference:9859790] White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
[LiteratureReference:9859804] N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo
[LiteratureReference:9860353] Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity
[LiteratureReference:9858985] Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis
modified[InstanceEdit:9907517] Orlic-Milacic, Marija, 2024-04-11
[InstanceEdit:9907535] Orlic-Milacic, Marija, 2024-04-12
[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
[InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07
[InstanceEdit:9918005] Orlic-Milacic, Marija, 2024-08-14
[InstanceEdit:9918105] Orlic-Milacic, Marija, 2024-08-14
[InstanceEdit:9918119] Orlic-Milacic, Marija, 2024-08-14
[InstanceEdit:9919218] Orlic-Milacic, Marija, 2024-08-19
[InstanceEdit:9927588] Matthews, Lisa, 2024-11-08
[InstanceEdit:9928382] Matthews, Lisa, 2024-11-15
[InstanceEdit:9971024] Orlic-Milacic, Marija, 2025-11-04
nameAngptl4 gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex
output[EntityWithAccessionedSequence:9917971] Angptl4 [extracellular region] [Mus musculus]
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveGeneExpressionRegulation:9918067] Positive gene expression regulation by 'Activated Pparg:Rxra:Angptl4 gene:H3K4me1-Nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm]'
releaseDate2024-09-11
reviewed[InstanceEdit:9970977] Khag, Joy, 2025-10-31
[InstanceEdit:9970978] Wang, Shu-Ping, 2025-10-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9907164] R-MMU-9907162.3
structureModified[InstanceEdit:9918005] Orlic-Milacic, Marija, 2024-08-14
[InstanceEdit:9918105] Orlic-Milacic, Marija, 2024-08-14
summation[Summation:9907163] In mouse preadipocyte cell line 3T3-L1, Angptl4 expression i...
(inferredFrom)[BlackBoxEvent:9859121] ANGPTL4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971850] Update Tracker - [BlackBoxEvent:9907162] Angptl4 gene expression is stimulated by Pparg:Rxra and Mll4,(Mll3) complex - v95:[removeLiteratureReference]
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