Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person MITF-M-dependent IRF4 gene expression

Class:IdBlackBoxEvent:9907147
_displayNameMITF-M-dependent IRF4 gene expression
_doReleaseTRUE
_timestamp2024-11-08 15:57:22
authored[InstanceEdit:9863554] Rothfels, Karen, 2024-03-01
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:9907146] Rothfels, Karen, 2024-04-04
edited[InstanceEdit:9907158] Rothfels, Karen, 2024-04-04
input[EntityWithAccessionedSequence:8948472] IRF4 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
isChimericFALSE
literatureReference[LiteratureReference:9907050] Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
[LiteratureReference:9907045] Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA
[LiteratureReference:5626280] Genetic determinants of hair, eye and skin pigmentation in Europeans
[LiteratureReference:9907082] A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
[LiteratureReference:9907066] A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
[LiteratureReference:9907033] TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes
modified[InstanceEdit:9907231] Rothfels, Karen, 2024-04-05
[InstanceEdit:9909022] Rothfels, Karen, 2024-04-25
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
nameMITF-M-dependent IRF4 gene expression
output[EntityWithAccessionedSequence:9907101] IRF4 [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveGeneExpressionRegulation:9907127] Positive gene expression regulation by 'MITF-M dimer:TFAP2A:IRF4 gene [nucleoplasm]'
regulationReference[RegulationReference:9907135] Positive gene expression regulation by 'MITF_M dimer:TFAP2A:IRF4 gene [nucleoplasm]' A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
releaseDate2024-06-15
reviewed[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9907149] R-HSA-9907147.2
summation[Summation:9907116] Interferon Regulatory Factor 4 (IRF4) is a winged-helix-turn...
(hasEvent)[Pathway:9824585] Regulation of MITF-M-dependent genes involved in pigmentation [Homo sapiens]
(precedingEvent)[Reaction:9907145] IRF4 binds the TYR promoter [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by MITF-M-dependent IRF4 gene expression (9907147)
Follow Reactome