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Details on Person UniProt:P28074 PSMB5
| Class:Id | ReferenceGeneProduct:99068 |
|---|---|
| _chainChangeLog | propeptide:1-59 added on Fri February 6 2015;chain:60-263 added on Fri February 6 2015 |
| _displayName | UniProt:P28074 PSMB5 |
| _timestamp | 2024-11-03 20:16:07 |
| chain | propeptide:1-59 chain:60-263 |
| checksum | AED4A73DF41AA6EF |
| comment | FUNCTION Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.CATALYTIC ACTIVITY Cleavage of peptide bonds with very broad specificity.SUBUNIT The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, PubMed:26133119, PubMed:27342858, PubMed:27428775, PubMed:27493187, PubMed:34711951, PubMed:8163024). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, PubMed:26133119, PubMed:27342858, PubMed:27428775, PubMed:27493187, PubMed:34711951, PubMed:8163024). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, PubMed:26133119, PubMed:27342858, PubMed:27428775, PubMed:27493187, PubMed:34711951, PubMed:8163024). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, PubMed:26133119, PubMed:27342858, PubMed:27428775, PubMed:27493187, PubMed:34711951, PubMed:8163024). Directly interacts with POMP (PubMed:15944226). Interacts with ABCB1 and TAP1 (PubMed:15488952).SUBUNIT (Microbial infection) Interacts with HIV-1 TAT protein.INTERACTION Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.ALTERNATIVE PRODUCTS Down-regulated by IFNG/IFN-gamma (at protein level). Induced in breast cancer tissue. Up-regulated by sulforaphane in breast cancer cells.SIMILARITY Belongs to the peptidase T1B family. |
| description | recommendedName: fullName evidence="28"Proteasome subunit beta type-5 ecNumber evidence="15"3.4.25.1 alternativeName: Macropain epsilon chain alternativeName: Multicatalytic endopeptidase complex epsilon chain alternativeName: Proteasome chain 6 alternativeName: Proteasome epsilon chain alternativeName: Proteasome subunit MB1 alternativeName: Proteasome subunit X alternativeName: fullName evidence="26"Proteasome subunit beta-5 shortName evidence="26"beta-5 |
| geneName | PSMB5 LMPX MB1 X |
| identifier | P28074 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Direct protein sequencing Host-virus interaction Hydrolase Nucleus Protease Proteasome Proteomics identification Reference proteome Threonine protease Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PSMB5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957422] ENSEMBL:ENSG00000100804 PSMB5 [Homo sapiens] |
| secondaryIdentifier | PSB5_HUMAN B2R4N9 B4DUM9 D3DS43 E9PAV2 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9 |
| sequenceLength | 263 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971138] UniProt:P28074-1 PSMB5 [Homo sapiens] [ReferenceIsoform:8971139] UniProt:P28074-2 PSMB5 [Homo sapiens] [ReferenceIsoform:8971140] UniProt:P28074-3 PSMB5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68753] PSMB5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174344] PSMB5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8957511] PSMB5 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9908134] PSMB5(1-59) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9908135] pro-PSMB5 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P28074 PSMB5 (99068)
