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Details on Person Activation of AKT1 by shear stress in osteocytes

Class:Id	BlackBoxEvent:9906597
_displayName	Activation of AKT1 by shear stress in osteocytes
_doRelease	TRUE
_timestamp	2024-11-05 13:25:26
authored	[InstanceEdit:9906591] May, Bruce, 2024-03-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9906596] May, Bruce, 2024-03-31
edited	[InstanceEdit:9906591] May, Bruce, 2024-03-30
inferredFrom	[BlackBoxEvent:9906595] Activation of Akt1 by shear stress in osteocytes [Mus musculus]
input	[Complex:377453] AKT1:PIP3 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9909074] Matthews, Lisa, 2024-04-26
isChimeric	FALSE
modified	[InstanceEdit:9906805] May, Bruce, 2024-04-02 [InstanceEdit:9924062] May, Bruce, 2024-10-06 [InstanceEdit:9925860] May, Bruce, 2024-10-27 [InstanceEdit:9927250] May, Bruce, 2024-11-05
name	Activation of AKT1 by shear stress in osteocytes
output	[EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9905934] CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9905964] P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol [Homo sapiens] [Reaction:9905952] ATP binds P2RX7 in P2RX7 trimer:PANX1 heptamer [Homo sapiens]
regulatedBy	[PositiveRegulation:71542] Positive regulation by 'Ca2+ [cytosol]' [PositiveRegulation:9924035] Positive regulation by 'Integrin alphaVbeta3:SPP1 [plasma membrane]'
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9906601] R-HSA-9906597.1
structureModified	[InstanceEdit:9924062] May, Bruce, 2024-10-06
summation	[Summation:9906592] In response to mechanical loading, the integrin alphaVbeta3 ...
(hasEvent)	[Pathway:9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes [Homo sapiens]
(precedingEvent)	[Reaction:9857661] p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43) [Homo sapiens] [Reaction:9857673] p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1) [Homo sapiens]
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