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Details on Person P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol

Class:IdReaction:9905964
_displayNameP2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol
_doReleaseTRUE
_timestamp2024-11-05 13:27:14
authored[InstanceEdit:9892589] May, Bruce, 2024-03-28
catalystActivity[CatalystActivity:9905926] extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9905924] May, Bruce, 2024-03-29
edited[InstanceEdit:9892589] May, Bruce, 2024-03-28
inferredFrom
input[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
internalReviewed[InstanceEdit:9909074] Matthews, Lisa, 2024-04-26
isChimericFALSE
literatureReference[LiteratureReference:9907476] The ATP4- receptor-operated channel (P2Z class) of human lymphocytes allows Ba2+ and ethidium+ uptake: inhibition of fluxes by suramin
[LiteratureReference:9907469] Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel
[LiteratureReference:9907449] Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues
[LiteratureReference:9907455] The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA
[LiteratureReference:9907605] Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents
modified[InstanceEdit:9906003] May, Bruce, 2024-03-29
[InstanceEdit:9907495] May, Bruce, 2024-04-10
[InstanceEdit:9907611] May, Bruce, 2024-04-13
[InstanceEdit:9925860] May, Bruce, 2024-10-27
[InstanceEdit:9927250] May, Bruce, 2024-11-05
nameP2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol
output[SimpleEntity:74016] Ca2+ [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
precedingEvent
releaseDate2024-12-04
reviewed[InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27
[InstanceEdit:9925859] Wu, Danielle, 2024-10-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9905981] R-HSA-9905964.1
structureModified[InstanceEdit:9906003] May, Bruce, 2024-03-29
summation[Summation:9907474] ATP activates the P2RX7 (P2X7, P2Z) trimer to passively tran...
(hasEvent)[Pathway:9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes [Homo sapiens]
(precedingEvent)[Reaction:9857702] Pannexin1 (PANX1) channel transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region [Homo sapiens]
[Reaction:9905999] Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region [Homo sapiens]
[BlackBoxEvent:9906597] Activation of AKT1 by shear stress in osteocytes [Homo sapiens]
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No pathways have been reviewed or authored by P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol (9905964)
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