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Details on Person Recruitment of ITCH and K48 ubiquitination of MAVS

Class:IdReaction:990526
_displayNameRecruitment of ITCH and K48 ubiquitination of MAVS
_doReleaseTRUE
_timestamp2023-05-18 15:05:27
authored[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity[CatalystActivity:990525] ubiquitin protein ligase activity of ITCH [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:17906] mitochondrial outer membrane
created[InstanceEdit:990524] Garapati, P V, 2010-11-03
edited[InstanceEdit:918228] Garapati, P V, 2010-08-02
input[EntityWithAccessionedSequence:975995] ITCH [cytosol] [Homo sapiens]
[Complex:983462] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] [Homo sapiens]
[Polymer:912740] K48polyUb [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:983448] PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
modified[InstanceEdit:994081] Garapati, P V, 2010-11-05
[InstanceEdit:998145] Garapati, P V, 2010-11-09
[InstanceEdit:1022090] Garapati, P V, 2010-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8983918] Jupe, Steve, 2017-03-31
[InstanceEdit:9014715] Shamovsky, Veronica, 2017-08-02
[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9758828] Shamovsky, Veronica, 2021-11-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9835846] Shamovsky, Veronica, 2023-05-18
nameRecruitment of ITCH and K48 ubiquitination of MAVS
output[Complex:983459] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:5621375] Hepatitis C Virus
[Species:9013948] Measles virus
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
[Species:9717528] Human respiratory syncytial virus A
releaseDate2010-12-14
reviewed[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105976] R-HSA-990526.6
summation[Summation:983444] On viral infection PCB2 binds MAVS (IPS-1) and recruits the ...
(hasEvent)[Pathway:936440] Negative regulators of DDX58/IFIH1 signaling [Homo sapiens]
(inferredFrom)[Reaction:1227860] ITCH homolog downregulates MDA5/IPS1 signaling [Gallus gallus]
(updatedInstance)[_UpdateTracker:9928517] Update Tracker - [Reaction:990526] Recruitment of ITCH and K48 ubiquitination of MAVS - v91:[modifyText]
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