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Details on Person Kinesin-14 proteins have a C-terminal motor domain. At least...
| Class:Id | Summation:990518 |
|---|---|
| _displayName | Kinesin-14 proteins have a C-terminal motor domain. At least... |
| _timestamp | 2010-11-08 17:42:08 |
| created | [InstanceEdit:990475] Jupe, S, 2010-11-03 |
| literatureReference | [LiteratureReference:990490] A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis [LiteratureReference:990481] The Drosophila claret segregation protein is a minus-end directed motor molecule |
| modified | [InstanceEdit:997250] Jupe, S, 2010-11-08 |
| text | Kinesin-14 proteins have a C-terminal motor domain. At least four members of the group (Dm Ncd, Sc KAR3, Cg CHO2, At KCBP) have been demonstrated to be minus-end directed motors (Walker et al. 1990), in contrast to the usual plus-end directed motility of other kinesin proteins. During spindle formation, Kinesin-14 cross-links antiparallel microtubules and slides them together (thereby generating inward forces) to balance the outward forces generated by plus-end-directed kinesins of the Kinesin-5 family. Kinesin-14 family members also gather microtubule minus-ends and focus them into spindle poles. Mutation or inhibition of Kinesin-14 family members often results in disordered or splayed meiotic spindle poles (Ambrose et al. 2005). |
| (summation) | [Reaction:990478] Kinesin-14 is a dimer [Homo sapiens] |
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No pathways have been reviewed or authored by Kinesin-14 proteins have a C-terminal motor domain. At least... (990518)
