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Details on Person UniProt:P17980 PSMC3
| Class:Id | ReferenceGeneProduct:98959 |
|---|---|
| _chainChangeLog | chain:1-439 added on Fri February 6 2015 |
| _displayName | UniProt:P17980 PSMC3 |
| _timestamp | 2024-11-03 19:53:25 |
| chain | chain:1-439 |
| checksum | 0E443465DDDEBB0B |
| comment | FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27342858, PubMed:27428775). Interacts with PAAF1 (PubMed:15831487).SUBUNIT (Microbial infection) Interacts with HIV-1 Tat.INTERACTION Colocalizes with TRIM5 in the cytoplasmic bodies.PTM Sumoylated by UBE2I in response to MEKK1-mediated stimuli.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AAA ATPase family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: 26S proteasome regulatory subunit 6A alternativeName: 26S proteasome AAA-ATPase subunit RPT5 alternativeName: Proteasome 26S subunit ATPase 3 alternativeName: Proteasome subunit P50 alternativeName: Tat-binding protein 1 shortName: TBP-1 |
| geneName | PSMC3 TBP1 |
| identifier | P17980 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cataract Cytoplasm Deafness Direct protein sequencing Host-virus interaction Intellectual disability Neuropathy Nucleotide-binding Nucleus Phosphoprotein Proteasome Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PSMC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001993] ENSEMBL:ENSG00000165916 PSMC3 [Homo sapiens] |
| secondaryIdentifier | PRS6A_HUMAN B2R8V1 Q3B757 Q3B865 Q53HU5 Q6GPG8 Q6IBS1 Q96HD3 |
| sequenceLength | 439 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68774] PSMC3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174313] PSMC3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6800429] PSMC3 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6800470] PSMC3 [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6800917] PSMC3 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806496] PSMC3 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P17980 PSMC3 (98959)
