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Details on Person UniProt:P35998 PSMC2
| Class:Id | ReferenceGeneProduct:98951 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-433 added on Fri February 6 2015;initiator methionine:1 for 98951 removed on Fri Nov 03 2023;initiator methionine: for 98951 added on Fri Nov 03 2023;initiator methionine: for 98951 removed on Fri Aug 15 2025;initiator methionine:1 for 98951 added on Fri Aug 15 2025 |
| _displayName | UniProt:P35998 PSMC2 |
| _timestamp | 2025-08-15 21:10:13 |
| chain | initiator methionine:1 chain:2-433 |
| checksum | 85FD95F6DF7A3E84 |
| comment | FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (PubMed:27342858, PubMed:27428775). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components (PubMed:27342858, PubMed:27428775). Interacts with NDC80/HEC; this interaction is detected only during M phase (PubMed:10409732, PubMed:9295362). Interacts and SQSTM1 (PubMed:15340068). Interacts with PAAF1 (PubMed:15831487). Directly interacts with TRIM5 (PubMed:22078707).SUBUNIT (Microbial infection) Interacts with HIV-1 Tat.INTERACTION Colocalizes with TRIM5 in cytoplasmic bodies.ALTERNATIVE PRODUCTS Expression is not cell cycle-dependent and occurs throughout the cell cycle.PTM Monoubiquitinated by RNF181.PTM Phosphorylated (PubMed:28539385). Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385).SIMILARITY Belongs to the AAA ATPase family. |
| description | recommendedName: 26S proteasome regulatory subunit 7 alternativeName: 26S proteasome AAA-ATPase subunit RPT1 alternativeName: Proteasome 26S subunit ATPase 2 |
| geneName | PSMC2 MSS1 |
| identifier | P35998 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Direct protein sequencing Nucleotide-binding Phosphoprotein Proteasome Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PSMC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993250] ENSEMBL:ENSG00000161057 PSMC2 [Homo sapiens] |
| secondaryIdentifier | PRS7_HUMAN A4D0Q1 B7Z5E2 Q3LIA5 Q9UDI3 |
| sequenceLength | 433 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965305] UniProt:P35998-1 PSMC2 [Homo sapiens] [ReferenceIsoform:8965306] UniProt:P35998-2 PSMC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68771] PSMC2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174332] PSMC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6800421] PSMC2 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6800453] PSMC2 [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6800994] PSMC2 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806472] PSMC2 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P35998 PSMC2 (98951)
