Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:P62191 PSMC1

Class:Id	ReferenceGeneProduct:98941
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-440 added on Fri February 6 2015;initiator methionine:1 for 98941 removed on Fri Nov 03 2023;initiator methionine: for 98941 added on Fri Nov 03 2023;initiator methionine: for 98941 removed on Fri Aug 15 2025;initiator methionine:1 for 98941 added on Fri Aug 15 2025
_displayName	UniProt:P62191 PSMC1
_timestamp	2025-08-15 21:55:54
chain	initiator methionine:1 chain:2-440
checksum	ACA80782F4F96F49
comment	FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC1 and few additional components (PubMed:27342858, PubMed:27428775). Interacts with SCA7 (PubMed:11734547). Interacts with NGLY1 (PubMed:15358861). Interacts with PAAF1 (PubMed:15831487).INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AAA ATPase family.
created	[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
description	recommendedName: 26S proteasome regulatory subunit 4 shortName: P26s4 alternativeName: 26S proteasome AAA-ATPase subunit RPT2 alternativeName: Proteasome 26S subunit ATPase 1
geneName	PSMC1
identifier	P62191
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Deafness Direct protein sequencing Intellectual disability Isopeptide bond Lipoprotein Membrane Myristate Nucleotide-binding Nucleus Phosphoprotein Proteasome Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	PSMC1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8998537] ENSEMBL:ENSG00000100764 PSMC1 [Homo sapiens]
secondaryIdentifier	PRS4_HUMAN B4DR63 P49014 Q03527 Q6IAW0 Q6NW36 Q96AZ3
sequenceLength	440
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8967992] UniProt:P62191-1 PSMC1 [Homo sapiens] [ReferenceIsoform:8967993] UniProt:P62191-2 PSMC1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:68768] PSMC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174338] PSMC1 [nucleoplasm] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:P62191 PSMC1 (98941)