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Details on Person UniProt:P23204 Ppara
| Class:Id | ReferenceGeneProduct:98723 |
|---|---|
| _chainChangeLog | chain:1-468 added on Sat February 7 2015 |
| _displayName | UniProt:P23204 Ppara |
| _timestamp | 2025-02-21 19:21:27 |
| chain | chain:1-468 |
| checksum | 2930A5191C610B6B |
| comment | FUNCTION Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.SUBUNIT Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD(+) levels (By similarity). Interacts with CRY1 and CRY2 (PubMed:28683290). In hepatocytes, interacts with PAQR3 and HUWE1; the interactions promote PPARA poylubiquitination and HUWE1-mediated degradation (PubMed:29331071).INTERACTION Highly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.DEVELOPMENTAL STAGE It appears first at 13.5 dpc and increases until birth.PTM Ubiquitinated by E3 ubiquitin-protein ligase HUWE1; leading to proteasomal degradation.PTM Phosphorylated.DISEASE Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs, herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia.SIMILARITY Belongs to the nuclear hormone receptor family. NR1 subfamily. |
| description | recommendedName: Peroxisome proliferator-activated receptor alpha shortName: PPAR-alpha alternativeName: Nuclear receptor subfamily 1 group C member 1 |
| geneName | Ppara Nr1c1 Ppar |
| identifier | P23204 |
| isSequenceChanged | FALSE |
| keyword | Activator Biological rhythms DNA-binding Lipid-binding Metal-binding Nucleus Receptor Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Ppara |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PPARA_MOUSE |
| sequenceLength | 468 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:879702] Ppara [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P23204 Ppara (98723)
