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Details on Person UniProt:P12982 Pp1-87B
Class:Id
ReferenceGeneProduct:98697
_chainChangeLog
chain:1-302 added on Fri February 6 2015
_displayName
UniProt:P12982 Pp1-87B
_timestamp
2025-02-21 19:00:26
chain
chain:1-302
checksum
68FE054996C9A062
comment
FUNCTION Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase.CATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateCOFACTOR Binds 2 manganese ions per subunit.SUBUNIT Interacts with Nop17l (PubMed:17007873). Interacts with uri; uri inhibits Pp1-87B phosphatase activity (PubMed:18412953). Interacts with Rif1 (PubMed:26022086, PubMed:29746464).INTERACTION Detected in embryos and larvae (at protein level).SIMILARITY Belongs to the PPP phosphatase family. PP-1 subfamily.
