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Details on Person Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH

Class:Id	Reaction:9866132
_displayName	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
_doRelease	TRUE
_timestamp	2025-03-04 15:56:55
authored	[InstanceEdit:9866112] Stephan, Ralf, 2024-03-22
catalystActivity	[CatalystActivity:9907159] protein binding activity of Intermediate II [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9866131] Stephan, Ralf, 2024-03-22
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
inferredFrom	[Reaction:9866128] CYTB:QCR7:QCR8 binds CYT1, COR1, COR2, QCR6 [Saccharomyces cerevisiae]
input	[Complex:164584] CYC1:heme c [mitochondrial inner membrane] [Homo sapiens] [Complex:9866106] Intermediate II [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:164284] UQCRC1 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:164280] UQCRC2 [mitochondrial inner membrane] [Homo sapiens] [CandidateSet:9932280] UQCRH, (UQCRHL) [mitochondrial inner membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9907743] D'Eustachio, Peter, 2024-04-16
isChimeric	FALSE
literatureReference	[LiteratureReference:9865877] Biogenesis of the bc₁ Complex of the Mitochondrial Respiratory Chain [LiteratureReference:9865886] Assembly of the Multi-Subunit Cytochrome bc₁ Complex in the Yeast Saccharomyces cerevisiae [LiteratureReference:9866083] Architecture of Human Mitochondrial Respiratory Megacomplex I₂III₂IV₂ [LiteratureReference:9932269] UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells
modified	[InstanceEdit:9866146] Stephan, Ralf, 2024-03-22 [InstanceEdit:9906004] Stephan, Ralf, 2024-03-29 [InstanceEdit:9907160] Stephan, Ralf, 2024-04-04 [InstanceEdit:9907742] Stephan, Ralf, 2024-04-16 [InstanceEdit:9910655] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910683] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910823] Stephan, Ralf, 2024-05-21 [InstanceEdit:9932282] Rothfels, Karen, 2024-12-18 [InstanceEdit:9932286] Rothfels, Karen, 2024-12-18 [InstanceEdit:9939591] Matthews, Lisa, 2025-03-04
name	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
output	[Complex:9866126] Late core complex monomer [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:9866062] UQCC3 [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9866104] Intermediate I binds second heme, UQCRB, UQCRQ [Homo sapiens] [BlackBoxEvent:9866061] Intermediate 0 binds heme and UQCC3 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2024-06-15
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16 [InstanceEdit:9939460] D'Eustachio, Peter, 2025-02-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9866142] R-HSA-9866132.2
structureModified	[InstanceEdit:9907160] Stephan, Ralf, 2024-04-04 [InstanceEdit:9932282] Rothfels, Karen, 2024-12-18
summation	[Summation:9866130] The Intermediate II complex ("early core") binds the Complex...
(hasEvent)	[Pathway:9865881] Complex III assembly [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9866061] Intermediate 0 binds heme and UQCC3 [Homo sapiens] [Reaction:9866162] Late core complex dimerizes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939771] Update Tracker - [Reaction:9866132] Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH - v92:[add_removeInput, modifyText, removeLiteratureReference]
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