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Details on Person TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)

Class:Id	Reaction:9865670
_displayName	TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)
_doRelease	TRUE
_timestamp	2024-07-16 10:30:37
authored	[InstanceEdit:9865661] May, Bruce, 2024-03-16
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9865672] May, Bruce, 2024-03-17
edited	[InstanceEdit:9865661] May, Bruce, 2024-03-16
input	[Complex:9858825] TRPV4 tetramer [plasma membrane] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9863414] Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site [LiteratureReference:9865675] Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4
modified	[InstanceEdit:9915811] May, Bruce, 2024-07-16
name	TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)
output	[Complex:9865674] TRPV4 tetramer:CALM1:Ca2+ [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:74448] Calcium binds calmodulin [Homo sapiens] [Reaction:139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol [Homo sapiens] [Reaction:434798] CRAC translocates calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:2089943] TRPC1 translocates calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:9700718] T-type VDCC transports Ca2+ from extracellular region to cytosol [Homo sapiens] [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens] [Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865676] R-HSA-9865670.1
summation	[Summation:9865673] Calmodulin (CALM1) in a complex with Ca2+ binds a domain in ...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens]
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No pathways have been reviewed or authored by TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) (9865670)