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Details on Person MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex

Class:Id	BlackBoxEvent:9865663
_displayName	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
_doRelease	TRUE
_timestamp	2024-05-21 07:55:44
authored	[InstanceEdit:9865665] Stephan, Ralf, 2024-03-17
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9865664] Stephan, Ralf, 2024-03-17
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
goBiologicalProcess	[GO_BiologicalProcess:261940] mitochondrial respiratory chain complex IV assembly
input	[Complex:9864495] MT-CO3:PE:CL [mitochondrial inner membrane] [Homo sapiens] [Complex:9864472] NDUFA4:CL [mitochondrial inner membrane] [Homo sapiens] [DefinedSet:5336144] COX7A1,2,2L [mitochondrial inner membrane] [Homo sapiens] [Complex:9864460] COX6A:PE [mitochondrial inner membrane] [Homo sapiens] [DefinedSet:5336172] COX6B1,2 [mitochondrial inner membrane] [Homo sapiens] [Complex:9865576] holo-MT-CO1,2 complex [mitochondrial inner membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9907743] D'Eustachio, Peter, 2024-04-16
isChimeric	FALSE
literatureReference	[LiteratureReference:8932164] Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex [LiteratureReference:9865688] Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis [LiteratureReference:9865684] HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function [LiteratureReference:9865685] HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV [LiteratureReference:9865141] Mitochondrial cytochrome c oxidase biogenesis: Recent developments [LiteratureReference:9865701] Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis [LiteratureReference:6803186] NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease
modified	[InstanceEdit:9865667] Stephan, Ralf, 2024-03-17 [InstanceEdit:9865694] Stephan, Ralf, 2024-03-18 [InstanceEdit:9865716] Stephan, Ralf, 2024-03-18 [InstanceEdit:9865737] Stephan, Ralf, 2024-03-18 [InstanceEdit:9902101] Stephan, Ralf, 2024-03-28 [InstanceEdit:9907742] Stephan, Ralf, 2024-04-16 [InstanceEdit:9910655] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910683] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910823] Stephan, Ralf, 2024-05-21
name	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
output	[Complex:164316] Cytochrome c oxidase [mitochondrial inner membrane] [Homo sapiens] [Complex:9865338] MITRAC [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9865579] MT-CO1 and MT-CO2 complexes associate, installing heme moieties [Homo sapiens] [BlackBoxEvent:9865569] MT-CO2 mRNA is translated [Homo sapiens] [Reaction:9865449] Metallochaperone inserts Cu2+ into MT-CO1 [Homo sapiens] [Reaction:9865630] Metallochaperone inserts 2Cu2+ into MT-CO2 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveRegulation:9865695] Positive regulation by 'HIGD1A [mitochondrial inner membrane]' [PositiveRegulation:9865696] Positive regulation by 'HIGD2A [mitochondrial inner membrane]' [PositiveRegulation:9865704] Positive regulation by 'RAB5IF [mitochondrial inner membrane]'
regulationReference	[RegulationReference:9865692] Positive regulation by 'HIGD1A [mitochondrial inner membrane]' Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis [RegulationReference:9865693] Positive regulation by 'HIGD2A [mitochondrial inner membrane]' Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis [RegulationReference:9865712] Positive regulation by 'RAB5IF [mitochondrial inner membrane]' Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis
releaseDate	2024-06-15
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865666] R-HSA-9865663.1
structureModified	[InstanceEdit:9865694] Stephan, Ralf, 2024-03-18 [InstanceEdit:9865716] Stephan, Ralf, 2024-03-18
summation	[Summation:9865668] The final assembly of Complex IV consists of binding of the ...
(hasEvent)	[Pathway:9864848] Complex IV assembly [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9865350] Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL [Homo sapiens]
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No pathways have been reviewed or authored by MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (9865663)