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Details on Person PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin

Class:Id	Reaction:9865520
_displayName	PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin
_doRelease	TRUE
_timestamp	2024-07-16 10:12:51
authored	[InstanceEdit:9865305] May, Bruce, 2024-03-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9865495] May, Bruce, 2024-03-13
edited	[InstanceEdit:9865305] May, Bruce, 2024-03-09
inferredFrom	[Reaction:9865867] PPP2CA and PPP2R1A bind PPP2R2A:p-S585-PDE4D:ITGA5:ITGB1:fibronectin [Bos taurus]
input	[Complex:9865518] p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:165971] PPP2CA [cytosol] [Homo sapiens] [CandidateSet:165990] PP2A-subunit A [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9865872] May, Bruce, 2024-03-20 [InstanceEdit:9865995] May, Bruce, 2024-03-20 [InstanceEdit:9915800] May, Bruce, 2024-07-16
name	PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin
output	[Complex:9865499] p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9865501] PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [Homo sapiens] [Reaction:9865182] p-S715-PDE4D5 binds p-S26-ANXA2:integrin alpha5:integrin beta1:fibronectin (p-S26-ANXA2:ITGA5:ITGB1:fibronectin) [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865536] R-HSA-9865520.1
summation	[Summation:9865985] The PP2A phosphatase complex, including the catalytic subuni...
(hasEvent)	[Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9865226] PP2A dephosphorylates serine-127 of YAP1 [Homo sapiens] [Reaction:9865238] PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin [Homo sapiens]
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No pathways have been reviewed or authored by PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (9865520)