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Details on Person Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE

Class:Id	BlackBoxEvent:9865511
_displayName	Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE
_doRelease	TRUE
_timestamp	2024-07-16 10:19:02
authored	[InstanceEdit:9865305] May, Bruce, 2024-03-09
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9865495] May, Bruce, 2024-03-13
edited	[InstanceEdit:9865305] May, Bruce, 2024-03-09
input	[EntityWithAccessionedSequence:629622] STAT1 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9865489] Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway [LiteratureReference:9865980] Low shear stress damages endothelial function through STAT1 in endothelial cells (ECs)
modified	[InstanceEdit:9865682] May, Bruce, 2024-03-18 [InstanceEdit:9865995] May, Bruce, 2024-03-20 [InstanceEdit:9866101] May, Bruce, 2024-03-21 [InstanceEdit:9915801] May, Bruce, 2024-07-16
name	Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE
output	[SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:8951202] p-Y701-STAT1 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9865492] Phosphorylation of IKBKE on serine-172 in response to low shear stress [Homo sapiens]
regulatedBy	[PositiveRegulation:9865994] Positive regulation by 'p-S172-IKBKE:p-S172-IKBKE [cytosol]'
regulationReference	[RegulationReference:9865988] Positive regulation by 'p-S172-IKBKE:p-S172-IKBKE [cytosol]' Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865533] R-HSA-9865511.1
structureModified	[InstanceEdit:9865682] May, Bruce, 2024-03-18 [InstanceEdit:9865995] May, Bruce, 2024-03-20
summation	[Summation:9866100] Phosphorylated IKBKE (IKKepsilon) positively regulates the p...
(hasEvent)	[Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:8985943] p-Y701-STAT1 dimerizes [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (9865511)