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Details on Person Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway
| Class:Id | LiteratureReference:9865489 |
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| _displayName | Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway |
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| _timestamp | 2024-03-13 19:13:28 |
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| author | [Person:9865529] Lv, Yifei
[Person:9865498] Jiang, Zihao
[Person:9865493] Zhou, Wenying
[Person:9865531] Yang, Hongfeng
[Person:9865508] Jin, Guozhen
[Person:9865480] Wang, Dongchen
[Person:9865482] Kong, Chaohua
[Person:9865474] Qian, Zhiyuan
[Person:9865513] Gu, Yue
[Person:9865500] Chen, Shaoliang
[Person:9865514] Zhu, Linlin |
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| created | [InstanceEdit:9865495] May, Bruce, 2024-03-13 |
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| journal | Inflammation |
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| pubMedIdentifier | 38315275 |
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| title | Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway |
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| year | 2024 |
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| (literatureReference) | [BlackBoxEvent:8985983] p-Y701-STAT1 dimer translocates from the cytosol to the nucleus [Homo sapiens]
[Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
[BlackBoxEvent:9865492] Phosphorylation of IKBKE on serine-172 in response to low shear stress [Homo sapiens]
[BlackBoxEvent:9865511] Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE [Homo sapiens]
[Reaction:9865524] p-Y701-STAT1 binds the NLRP3 gene [Homo sapiens]
[RegulationReference:9865988] Positive regulation by 'p-S172-IKBKE:p-S172-IKBKE [cytosol]' Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway |
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