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Details on Person Metallochaperone inserts Cu2+ into MT-CO1

Class:IdReaction:9865449
_displayNameMetallochaperone inserts Cu2+ into MT-CO1
_doReleaseTRUE
_timestamp2024-05-21 07:56:29
authored[InstanceEdit:9865456] Stephan, Ralf, 2024-03-13
catalystActivity[CatalystActivity:9865627] copper chaperone activity of metallochaperone complex [mitochondrial inner membrane]
compartment[Compartment:70616] mitochondrial inner membrane
created[InstanceEdit:9865452] Stephan, Ralf, 2024-03-13
edited[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
input[Complex:9865410] MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C [mitochondrial inner membrane] [Homo sapiens]
[Complex:9865624] COX17:Cu [mitochondrial intermembrane space] [Homo sapiens]
internalReviewed[InstanceEdit:9907743] D'Eustachio, Peter, 2024-04-16
isChimericFALSE
literatureReference[LiteratureReference:9865140] Coordination of metal center biogenesis in human cytochrome c oxidase
[LiteratureReference:9865453] COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux
[LiteratureReference:9865450] Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase
[LiteratureReference:9865437] Role of Copper on Mitochondrial Function and Metabolism
modified[InstanceEdit:9865568] Stephan, Ralf, 2024-03-14
[InstanceEdit:9865626] Stephan, Ralf, 2024-03-16
[InstanceEdit:9865874] Stephan, Ralf, 2024-03-20
[InstanceEdit:9907742] Stephan, Ralf, 2024-04-16
[InstanceEdit:9910655] Stephan, Ralf, 2024-05-16
[InstanceEdit:9910683] Stephan, Ralf, 2024-05-16
[InstanceEdit:9910689] Stephan, Ralf, 2024-05-16
[InstanceEdit:9910823] Stephan, Ralf, 2024-05-21
nameMetallochaperone inserts Cu2+ into MT-CO1
output[Complex:9865438] MT-CO1:Cu2+:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C [mitochondrial inner membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1307788] COX17 [mitochondrial intermembrane space] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2024-06-15
reviewed[InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9865459] R-HSA-9865449.1
structureModified[InstanceEdit:9865626] Stephan, Ralf, 2024-03-16
summation[Summation:9865873] A metallochaperone complex consisting of nine subunits (COA3...
(hasEvent)[Pathway:9864848] Complex IV assembly [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9865579] MT-CO1 and MT-CO2 complexes associate, installing heme moieties [Homo sapiens]
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