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Details on Person Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL

Class:Id	BlackBoxEvent:9865350
_displayName	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL
_doRelease	TRUE
_timestamp	2025-03-05 21:00:26
authored	[InstanceEdit:9865324] Stephan, Ralf, 2024-03-10
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9865353] Stephan, Ralf, 2024-03-10
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
goBiologicalProcess	[GO_BiologicalProcess:7977] protein folding
input	[Complex:9865338] MITRAC [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:164314] nascent MT-CO1 [mitochondrial inner membrane] [Homo sapiens] [SimpleEntity:109496] Mg2+ [mitochondrial matrix] [SimpleEntity:1524083] PE [mitochondrial inner membrane] [SimpleEntity:1524072] cardiolipin [mitochondrial inner membrane]
internalReviewed	[InstanceEdit:9907743] D'Eustachio, Peter, 2024-04-16
isChimeric	FALSE
literatureReference	[LiteratureReference:8986109] MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation [LiteratureReference:9865349] MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly [LiteratureReference:9865346] A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis [LiteratureReference:9865352] SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome
modified	[InstanceEdit:9865414] Stephan, Ralf, 2024-03-12 [InstanceEdit:9865434] Stephan, Ralf, 2024-03-13 [InstanceEdit:9902101] Stephan, Ralf, 2024-03-28 [InstanceEdit:9907742] Stephan, Ralf, 2024-04-16 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9910655] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910683] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910823] Stephan, Ralf, 2024-05-21 [InstanceEdit:9940156] D'Eustachio, Peter, 2025-03-05
name	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL
output	[Complex:9865433] MT-CO1:Mg2+:PE:CL:MITRAC [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9865309] MT-CO1 mRNA is translated [Homo sapiens] [Reaction:9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC [Homo sapiens] [BlackBoxEvent:9865663] MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex [Homo sapiens] [BlackBoxEvent:9865579] MT-CO1 and MT-CO2 complexes associate, installing heme moieties [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865359] R-HSA-9865350.2
structureModified	[InstanceEdit:9865434] Stephan, Ralf, 2024-03-13
summation	[Summation:9865408] Nascent MT-CO1 binds to Mitochondrial Translation Regulation...
(hasEvent)	[Pathway:9864848] Complex IV assembly [Homo sapiens]
(precedingEvent)	[Reaction:9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC [Homo sapiens]
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No pathways have been reviewed or authored by Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (9865350)