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Details on Person PP2A dephosphorylates serine-127 of YAP1

Class:Id	Reaction:9865226
_displayName	PP2A dephosphorylates serine-127 of YAP1
_doRelease	TRUE
_timestamp	2024-07-16 10:12:01
authored	[InstanceEdit:9865237] May, Bruce, 2024-03-09
catalystActivity	[CatalystActivity:9865230] protein serine/threonine phosphatase activity of p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9865219] May, Bruce, 2024-03-09
edited	[InstanceEdit:9865237] May, Bruce, 2024-03-09
input	[EntityWithAccessionedSequence:2028553] p-S127-YAP1 [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9865158] Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis [LiteratureReference:9865292] Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness
modified	[InstanceEdit:9865305] May, Bruce, 2024-03-09 [InstanceEdit:9865540] May, Bruce, 2024-03-13 [InstanceEdit:9866198] May, Bruce, 2024-03-23 [InstanceEdit:9915800] May, Bruce, 2024-07-16
name	PP2A dephosphorylates serine-127 of YAP1
output	[EntityWithAccessionedSequence:1253345] YAP1 [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:9865520] PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [Homo sapiens] [Reaction:9865501] PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865279] R-HSA-9865226.1
summation	[Summation:9865479] Interaction between integrin alpha5 (ITGA5) and fibronectin ...
(hasEvent)	[Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 [Homo sapiens]
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No pathways have been reviewed or authored by PP2A dephosphorylates serine-127 of YAP1 (9865226)