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Details on Person p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1

Class:Id	Reaction:9865196
_displayName	p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1
_doRelease	TRUE
_timestamp	2024-07-16 10:28:34
authored	[InstanceEdit:9864838] May, Bruce, 2024-03-07
catalystActivity	[CatalystActivity:9865207] protein tyrosine kinase activity of p-Y393-ABL1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9865219] May, Bruce, 2024-03-09
edited	[InstanceEdit:9864838] May, Bruce, 2024-03-07
input	[EntityWithAccessionedSequence:1253345] YAP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9865247] c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow [LiteratureReference:8956641] Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
modified	[InstanceEdit:9865540] May, Bruce, 2024-03-13 [InstanceEdit:9865682] May, Bruce, 2024-03-18 [InstanceEdit:9866198] May, Bruce, 2024-03-23 [InstanceEdit:9915809] May, Bruce, 2024-07-16
name	p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1
output	[EntityWithAccessionedSequence:9865208] p-Y407-YAP1 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress [Homo sapiens] [Reaction:9865228] p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix [Homo sapiens] [Reaction:9865226] PP2A dephosphorylates serine-127 of YAP1 [Homo sapiens] [Reaction:9865520] PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865282] R-HSA-9865196.1
summation	[Summation:9865477] During turbulent flow across endothelial cells, ABL1 is acti...
(hasEvent)	[Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9865176] p-Y407-YAP1 translocates from the cytosol to the nucleoplasm [Homo sapiens]
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