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Details on Person p-Y407-YAP1 translocates from the cytosol to the nucleoplasm

Class:Id	BlackBoxEvent:9865176
_displayName	p-Y407-YAP1 translocates from the cytosol to the nucleoplasm
_doRelease	TRUE
_timestamp	2024-07-16 10:29:09
authored	[InstanceEdit:9864838] May, Bruce, 2024-03-07
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9865219] May, Bruce, 2024-03-09
edited	[InstanceEdit:9864838] May, Bruce, 2024-03-07
input	[EntityWithAccessionedSequence:9865208] p-Y407-YAP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9865247] c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow [LiteratureReference:9865300] Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis [LiteratureReference:9865506] Role of YAP/TAZ in mechanotransduction [LiteratureReference:9865517] Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance
modified	[InstanceEdit:9865305] May, Bruce, 2024-03-09 [InstanceEdit:9865540] May, Bruce, 2024-03-13 [InstanceEdit:9865617] May, Bruce, 2024-03-15 [InstanceEdit:9915809] May, Bruce, 2024-07-16
name	p-Y407-YAP1 translocates from the cytosol to the nucleoplasm
output	[EntityWithAccessionedSequence:8956661] p-Y407-YAP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9865196] p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 [Homo sapiens] [BlackBoxEvent:9865184] Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress [Homo sapiens] [Reaction:9865226] PP2A dephosphorylates serine-127 of YAP1 [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9865264] R-HSA-9865176.1
summation	[Summation:9865613] In response to turbulent flow across endothelial cells, YAP1...
(hasEvent)	[Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
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No pathways have been reviewed or authored by p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (9865176)