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Details on Person Clone of MDH2 dimer reduces OA to MAL

Class:Id	Reaction:9863545
_displayName	Clone of MDH2 dimer reduces OA to MAL
_timestamp	2024-03-01 12:10:03
catalystActivity	[CatalystActivity:70978] L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643763] L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9863540] Stephan, Ralf, 2024-03-01
input	[SimpleEntity:113587] OA [mitochondrial matrix] [SimpleEntity:29362] NADH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
literatureReference	[LiteratureReference:451039] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates [LiteratureReference:198468] Aggregation states of mitochondrial malate dehydrogenase
name	MDH2 dimer reduces OA to MAL H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)
output	[SimpleEntity:113544] MAL [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:9012268] ME2 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9861667] DLAT trimer transfers acetyl to CoA [Homo sapiens]
reverseReaction	[Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9863547] R-HSA-9863545.1
summation	[Summation:198465] Mitochondrial malate dehydrogenase (MDH2) catalyzes the hydr...
(replacementInstances)	[_Deleted:9863539] Deletion of instance: 71783
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No pathways have been reviewed or authored by Clone of MDH2 dimer reduces OA to MAL (9863545)