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Details on Person UniProt:Q80UV9-4 Taf1
| Class:Id | ReferenceIsoform:9862375 |
|---|---|
| _chainChangeLog | chain:1-1891 for 9862375 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q80UV9-4 Taf1 |
| _timestamp | 2025-09-27 13:10:42 |
| chain | chain:1-1891 |
| checksum | 9A4EA0475BB3E885 |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:10438527). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (By similarity). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (By similarity). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (By similarity). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (By similarity). Possesses DNA-binding activity (By similarity). Exhibits histone acetyltransferase activity towards histones H3 and H4 (By similarity). Essential for progression of the G1 phase of the cell cycle (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)COFACTOR Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity.SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs) (PubMed:10438527). TFIID consists of at least TBP, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF7; the interaction is direct. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (By similarity).INTERACTION The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions. The second domain also recognizes and binds histones that are butyrylated and crotonylated.PTM Phosphorylated by casein kinase II in vitro.SIMILARITY Belongs to the TAF1 family. |
| created | [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| description | recommendedName: fullName evidence="9"Transcription initiation factor TFIID subunit 1 ecNumber evidence="2"2.3.1.48 ecNumber: 2.7.11.1 alternativeName: Cell cycle gene 1 protein alternativeName: TBP-associated factor 250 kDa shortName: p250 alternativeName: Transcription initiation factor TFIID 250 kDa subunit shortName: TAF(II)250 shortName: TAFII-250 shortName: TAFII250 |
| geneName | Taf1 Ccg1 |
| identifier | Q80UV9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Acyltransferase Alternative initiation Alternative splicing ATP-binding Bromodomain Cell cycle DNA-binding Isopeptide bond Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase Transcription Transcription regulation Transferase Ubl conjugation |
| modified | [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9967293] May, Bruce, 2025-09-27 |
| name | Taf1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TAF1_MOUSE A2AM32 A2AM33 O35361 Q3UPF3 Q3V223 Q505F9 Q8BQH8 Q8BQQ7 Q8BR59 Q8C7N8 Q9WTW9 Q9WTX0 Q9WTX1 |
| sequenceLength | 1891 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q80UV9-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q80UV9-4 Taf1 (9862375)
