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Details on Person UniProt:G3X9P6 Obox5
| Class:Id | ReferenceGeneProduct:9862273 |
|---|---|
| _chainChangeLog | chain:1-291 for 9862273 added on Mon Feb 26 2024 |
| _displayName | UniProt:G3X9P6 Obox5 |
| _timestamp | 2024-05-14 17:30:17 |
| chain | chain:1-291 |
| checksum | A4BD8717A001CEE5 |
| comment | FUNCTION Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895).SUBCELLULAR LOCATION Specifically expressed in oocytes and early embryos.DEVELOPMENTAL STAGE Expressed maternally with high expression in oocytes and early embryos before expression declines after zygotic genome activation (ZGA).DISRUPTION PHENOTYPE No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895).SIMILARITY Belongs to the paired homeobox family. Obox subfamily. |
| created | [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| description | recommendedName: fullName evidence="5"Oocyte-specific homeobox protein 5 |
| geneName | Obox5 |
| identifier | G3X9P6 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 |
| name | Obox5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OBOX5_MOUSE G3UZE6 G3UZS7 Q7TPZ5 Q8VHG4 |
| sequenceLength | 291 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9841094] Obox5 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:G3X9P6 Obox5 (9862273)
