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Details on Person UniProt:Q3UT54 Obox3
| Class:Id | ReferenceGeneProduct:9862272 |
|---|---|
| _chainChangeLog | chain:1-335 for 9862272 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q3UT54 Obox3 |
| _timestamp | 2024-05-14 17:30:17 |
| chain | chain:1-335 |
| checksum | 436762645521D0F7 |
| comment | FUNCTION Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895).SUBCELLULAR LOCATION Specifically expressed in early embryos.DEVELOPMENTAL STAGE Expressed zygotically with expression starting at mid-two-cell stage, during major zygotic genome activation (ZGA), and peaking in late two-cell stage embryos.DISRUPTION PHENOTYPE No visible phenotype; mice are viable and fertile (PubMed:37459895). Female mice lacking maternally transcribed Obox1, Obox2, Obox5, Obox7 as well as zygotically expressed Obox3 and Obox4 are infertile: embryos arrest at two-four cell stage due to impaired zygotic genome activation (ZGA) (PubMed:37459895).SIMILARITY Belongs to the paired homeobox family. Obox subfamily. |
| created | [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| description | recommendedName: fullName evidence="7"Oocyte-specific homeobox protein 3 alternativeName: fullName evidence="6"Oocyte-specific homeobox |
| geneName | Obox3 Ohx |
| identifier | Q3UT54 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 |
| name | Obox3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OBOX3_MOUSE D3YXK4 G3UXQ8 G3UXT3 G3UZJ7 Q8JZN9 Q8VHG6 |
| sequenceLength | 335 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9841083] Obox3 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q3UT54 Obox3 (9862272)
