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Details on Person ME1 tetramer decarboxylates OA to PYR

Class:Id	Reaction:9861660
_displayName	ME1 tetramer decarboxylates OA to PYR
_doRelease	TRUE
_timestamp	2024-04-24 07:27:10
authored	[InstanceEdit:9861713] Stephan, Ralf, 2024-01-25
catalystActivity	[CatalystActivity:9861583] oxaloacetate decarboxylase activity of ME1 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9861650] Stephan, Ralf, 2024-02-21
crossReference	[DatabaseIdentifier:9861641] RHEA:15642
edited	[InstanceEdit:9862190] Stephan, Ralf, 2024-02-23
input	[SimpleEntity:76213] OA [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9861670] Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain [LiteratureReference:9012045] Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme [LiteratureReference:9012020] Structure and function of malic enzymes, a new class of oxidative decarboxylases [LiteratureReference:9012072] Structural characteristics of the nonallosteric human cytosolic malic enzyme [LiteratureReference:9012021] Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme
modified	[InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9863120] Stephan, Ralf, 2024-02-27 [InstanceEdit:9863463] Stephan, Ralf, 2024-02-29 [InstanceEdit:9863536] Stephan, Ralf, 2024-03-01 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	ME1 tetramer decarboxylates OA to PYR
output	[SimpleEntity:29398] PYR [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate [Homo sapiens] [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp [Homo sapiens] [Reaction:9861631] ME1 tetramerizes [Homo sapiens] [Reaction:9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 [Homo sapiens] [BlackBoxEvent:9761854] NFE2L2-dependent ME1 gene expression [Homo sapiens] [BlackBoxEvent:1989756] Expression of ME1 [Homo sapiens]
releaseDate	2024-03-27
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9861764] R-HSA-9861660.2
summation	[Summation:9861633] Cytosolic malic enzyme (ME1, aka c-NADP-ME) oxidatively deca...
(hasEvent)	[Pathway:70268] Pyruvate metabolism [Homo sapiens]
(precedingEvent)	[Reaction:71849] LDH tetramer reduces PYR to LACT [Homo sapiens] [Reaction:9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Homo sapiens] [Reaction:9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Homo sapiens]
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