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Details on Person Ca2+ activates Calpain2 (m-Calpain)

Class:Id	Reaction:9861511
_displayName	Ca2+ activates Calpain2 (m-Calpain)
_doRelease	TRUE
_timestamp	2024-07-16 10:04:54
authored	[InstanceEdit:9861357] May, Bruce, 2024-02-16
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9861467] May, Bruce, 2024-02-21
edited	[InstanceEdit:9861357] May, Bruce, 2024-02-16
input	[SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [Complex:8863624] Calpain2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8863614] A novel human small subunit of calpains [LiteratureReference:8863602] The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium [LiteratureReference:8868138] Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin [LiteratureReference:9863396] Domain II of m-calpain is a Ca(2+)-dependent cysteine protease
modified	[InstanceEdit:9863444] May, Bruce, 2024-02-29 [InstanceEdit:9863929] May, Bruce, 2024-03-05 [InstanceEdit:9866199] May, Bruce, 2024-03-23 [InstanceEdit:9915798] May, Bruce, 2024-07-16
name	Ca2+ activates Calpain2 (m-Calpain)
output	[Complex:8863404] Calpain2:Ca2+ [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens] [Reaction:9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9861520] R-HSA-9861511.1
summation	[Summation:9861510] Calpain2 (m-Calpain, CAPN2:CAPNS) is a heterodimeric proteas...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens] [Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9855106] Calpain2 (m-Calpain) cleaves TLN1 (Talin-1) [Homo sapiens] [Reaction:9861485] Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) [Homo sapiens]
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No pathways have been reviewed or authored by Ca2+ activates Calpain2 (m-Calpain) (9861511)