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Details on Person Calpain2 (m-Calpain, CAPN2:CAPNS) is a heterodimeric proteas...

Class:IdSummation:9861510
_displayNameCalpain2 (m-Calpain, CAPN2:CAPNS) is a heterodimeric proteas...
_timestamp2024-03-21 17:04:39
created[InstanceEdit:9861467] May, Bruce, 2024-02-21
literatureReference[LiteratureReference:9855162] Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity
[LiteratureReference:9861482] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions
[LiteratureReference:8863623] Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding
[LiteratureReference:9863424] Structural basis for possible calcium-induced activation mechanisms of calpains
[LiteratureReference:9863395] Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation
[LiteratureReference:9855132] Endothelial cell calpain as a critical modulator of angiogenesis
modified[InstanceEdit:9863444] May, Bruce, 2024-02-29
[InstanceEdit:9863929] May, Bruce, 2024-03-05
[InstanceEdit:9866101] May, Bruce, 2024-03-21
textCalpain2 (m-Calpain, CAPN2:CAPNS) is a heterodimeric protease complex containing a large, catalytic subunit (CAPN2) and a small subunit (CAPNS) (Schád et al. 2002). Calpain2 is activated by millimolar concentrations of calcium ions in vitro and micromolar concentrations in vivo (reviewed in Zhang et al. 2017). Calpain2 binds several calcium ions (Hata et al. 2001, Hanna et al. 2008, inferred from the porcine homolog in Lin et al. 1997) and calcium bound to a negatively charged loop of CAPN2 is believed to cause a change in conformation that brings the subdomains of the catalytic center together (Strobl et al. 2000, Hata et al. 2001, Reverter et al. 2001, inferred from the rat homolog in Hosfield et al. 1999). The protease activity of Calpain2 is activated in endothelial cells during laminar flow shear stress (Miyazaki et al. 2007) and during turbulent flow shear stress (Miyazaki et al. 2010).
(summation)[Reaction:9861511] Ca2+ activates Calpain2 (m-Calpain) [Homo sapiens]
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