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Details on Person Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)

Class:Id	Reaction:9861485
_displayName	Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)
_doRelease	TRUE
_timestamp	2024-07-16 10:05:36
authored	[InstanceEdit:9861357] May, Bruce, 2024-02-16
catalystActivity	[CatalystActivity:9861475] calcium-dependent cysteine-type endopeptidase activity of Calpain2:Ca2+ [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9861467] May, Bruce, 2024-02-21
edited	[InstanceEdit:9861357] May, Bruce, 2024-02-16
input	[EntityWithAccessionedSequence:350753] VCL [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9855162] Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity [LiteratureReference:9861482] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions
modified	[InstanceEdit:9863929] May, Bruce, 2024-03-05 [InstanceEdit:9866101] May, Bruce, 2024-03-21 [InstanceEdit:9915798] May, Bruce, 2024-07-16
name	Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)
output	[EntityWithAccessionedSequence:9861471] VCL(95 kDa) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9861511] Ca2+ activates Calpain2 (m-Calpain) [Homo sapiens] [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9861521] R-HSA-9861485.1
summation	[Summation:9863905] Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) activated by cytosoli...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens] [Pathway:9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Homo sapiens]
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No pathways have been reviewed or authored by Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (9861485)