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Details on Person ADM (Adrenomedullin) binds CALCRL:RAMP2

Class:Id	Reaction:9861332
_displayName	ADM (Adrenomedullin) binds CALCRL:RAMP2
_doRelease	TRUE
_timestamp	2024-07-16 10:02:11
authored	[InstanceEdit:9860942] May, Bruce, 2024-02-12
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9861304] May, Bruce, 2024-02-16
edited	[InstanceEdit:9860942] May, Bruce, 2024-02-12
input	[EntityWithAccessionedSequence:420093] ADM(95-146) [extracellular region] [Homo sapiens] [Complex:420232] CALCRL:RAMP2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:420203] RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor [LiteratureReference:9863669] The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor
modified	[InstanceEdit:9863689] May, Bruce, 2024-03-04 [InstanceEdit:9863929] May, Bruce, 2024-03-05 [InstanceEdit:9915796] May, Bruce, 2024-07-16
name	ADM (Adrenomedullin) binds CALCRL:RAMP2
output	[Complex:9861328] ADM:CALCRL:RAMP2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9861331] Secretion of ADM (Adrenomedullin) [Homo sapiens] [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9861353] R-HSA-9861332.1
summation	[Summation:9863655] Adrenomedullin (ADM) binds the heterodimeric receptor CALCRL...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9861300] ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer [Homo sapiens]
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No pathways have been reviewed or authored by ADM (Adrenomedullin) binds CALCRL:RAMP2 (9861332)