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Details on Person Secretion of ADM (Adrenomedullin)

Class:Id	BlackBoxEvent:9861331
_displayName	Secretion of ADM (Adrenomedullin)
_doRelease	TRUE
_timestamp	2024-07-16 10:44:13
authored	[InstanceEdit:9860942] May, Bruce, 2024-02-12
compartment	[Compartment:1462052] secretory granule lumen [Compartment:984] extracellular region
created	[InstanceEdit:9861304] May, Bruce, 2024-02-16
edited	[InstanceEdit:9860942] May, Bruce, 2024-02-12
input	[EntityWithAccessionedSequence:9861342] ADM(95-146) [secretory granule lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9861297] Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
modified	[InstanceEdit:9863614] May, Bruce, 2024-03-04 [InstanceEdit:9866199] May, Bruce, 2024-03-23 [InstanceEdit:9915818] May, Bruce, 2024-07-16
name	Secretion of ADM (Adrenomedullin)
output	[EntityWithAccessionedSequence:420093] ADM(95-146) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens] [Reaction:9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) [Homo sapiens]
regulatedBy	[PositiveRegulation:71542] Positive regulation by 'Ca2+ [cytosol]'
regulationReference	[RegulationReference:9861305] Positive regulation by 'Ca2+ [cytosol]' Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9861351] R-HSA-9861331.1
summation	[Summation:9863602] Stimulation of the mechanosensitive cation channel PIEZO1 by...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9861332] ADM (Adrenomedullin) binds CALCRL:RAMP2 [Homo sapiens]
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No pathways have been reviewed or authored by Secretion of ADM (Adrenomedullin) (9861331)