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Details on Person ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer

Class:Id	Reaction:9861300
_displayName	ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer
_doRelease	TRUE
_timestamp	2024-07-16 10:02:47
authored	[InstanceEdit:9860942] May, Bruce, 2024-02-12
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9861304] May, Bruce, 2024-02-16
edited	[InstanceEdit:9860942] May, Bruce, 2024-02-12
input	[Complex:9861328] ADM:CALCRL:RAMP2 [plasma membrane] [Homo sapiens] [Complex:432200] G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9863648] Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay [LiteratureReference:9863661] Structure and Dynamics of Adrenomedullin Receptors AM₁ and AM₂ Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins [LiteratureReference:9863670] Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs [LiteratureReference:9863920] Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors [LiteratureReference:9749365] Illuminating G-Protein-Coupling Selectivity of GPCRs
modified	[InstanceEdit:9863689] May, Bruce, 2024-03-04 [InstanceEdit:9863929] May, Bruce, 2024-03-05 [InstanceEdit:9915797] May, Bruce, 2024-07-16
name	ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer
output	[Complex:9861307] ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9861332] ADM (Adrenomedullin) binds CALCRL:RAMP2 [Homo sapiens] [BlackBoxEvent:9861331] Secretion of ADM (Adrenomedullin) [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9861346] R-HSA-9861300.1
summation	[Summation:9861334] The CALCRL:RAMP2 receptor bound to ADM binds the Gs alpha su...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9861324] ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP [Homo sapiens]
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No pathways have been reviewed or authored by ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer (9861300)