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Details on Person AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3)

Class:Id	Reaction:9860833
_displayName	AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3)
_doRelease	TRUE
_timestamp	2024-07-16 10:04:09
authored	[InstanceEdit:9860598] May, Bruce, 2024-02-07
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9860774] May, Bruce, 2024-02-10
edited	[InstanceEdit:9860598] May, Bruce, 2024-02-07
inferredFrom	[Reaction:9863573] Akt1 binds phosphoinositol-3,4,5-trisphosphate [Mus musculus]
input	[EntityWithAccessionedSequence:58252] AKT1 [cytosol] [Homo sapiens] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:9863608] High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate
modified	[InstanceEdit:9863614] May, Bruce, 2024-03-04 [InstanceEdit:9915798] May, Bruce, 2024-07-16
name	AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3)
output	[Complex:377453] AKT1:PIP3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9860816] Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate [Homo sapiens] [BlackBoxEvent:9860571] Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9860849] R-HSA-9860833.1
summation	[Summation:9863601] The Pleckstrin Homology (PH) domain of AKT1 (PKB) binds phos...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:9860759] p-T816-PKN2 phosphorylates AKT1 on serine-308 [Homo sapiens] [Reaction:9860800] mTORC2 phosphorylates AKT1 on serine-473 [Homo sapiens]
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No pathways have been reviewed or authored by AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3) (9860833)