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Details on Person p-S446-IRF5 dimer translocates to the nucleus

Class:Id	BlackBoxEvent:9860278
_displayName	p-S446-IRF5 dimer translocates to the nucleus
_doRelease	TRUE
_timestamp	2024-05-15 16:31:34
authored	[InstanceEdit:9860434] Shamovsky, Veronica, 2024-02-06
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9860252] Shamovsky, Veronica, 2024-02-01
edited	[InstanceEdit:9910548] Shamovsky, Veronica, 2024-05-15
input	[Complex:9860257] p-S446-IRF5:p-S446-IRF5 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9863340] Matthews, Lisa, 2024-02-29
isChimeric	FALSE
literatureReference	[LiteratureReference:9860266] Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5
modified	[InstanceEdit:9860434] Shamovsky, Veronica, 2024-02-06 [InstanceEdit:9863342] Shamovsky, Veronica, 2024-02-29 [InstanceEdit:9909271] Shamovsky, Veronica, 2024-05-02 [InstanceEdit:9909428] Shamovsky, Veronica, 2024-05-13 [InstanceEdit:9910553] Shamovsky, Veronica, 2024-05-15 [InstanceEdit:9910569] Shamovsky, Veronica, 2024-05-15
name	p-S446-IRF5 dimer translocates to the nucleus
output	[Complex:9860274] p-S446-IRF5:p-S446-IRF5 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9860273] Dimerization of p-S446-IRF5 [Homo sapiens] [Reaction:9860292] Activated IKBKB phosphorylates IRF5 [Homo sapiens]
releaseDate	2024-06-15
reviewed	[InstanceEdit:9909272] L�w, Christian, 2024-05-02 [InstanceEdit:9909426] Heinz, Leonhard X, 2024-05-13 [InstanceEdit:9910549] Toyama-Sorimachi, Noriko, 2024-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9860308] R-HSA-9860278.1
summation	[Summation:9860412] Upon stimulation, the transcription factor IRF5 is activated...
(hasEvent)	[Pathway:9860276] SLC15A4:TASL-dependent IRF5 activation [Homo sapiens]
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No pathways have been reviewed or authored by p-S446-IRF5 dimer translocates to the nucleus (9860278)