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Details on Person Sirt1 binds Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene

Class:Id	Reaction:9859951
_displayName	Sirt1 binds Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene
_timestamp	2026-03-23 17:44:32
authored	[InstanceEdit:9859681] May, Bruce, 2024-01-24
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9859836] May, Bruce, 2024-01-29
edited	[InstanceEdit:9859681] May, Bruce, 2024-01-24
input	[EntityWithAccessionedSequence:5211238] Sirt1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5211238] Sirt1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5211238] Sirt1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5211238] Sirt1 [nucleoplasm] [Mus musculus] [Complex:9859860] Ac-K544,p-Bmal1:p-Clock,Npas2:Nampt gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9985656] Gillespie, Marc E, 2026-03-23
isChimeric	FALSE
literatureReference	[LiteratureReference:1368959] Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1 [LiteratureReference:9770646] Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis [LiteratureReference:9859956] The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control [LiteratureReference:9958971] SIRT1 regulates circadian clock gene expression through PER2 deacetylation
modified	[InstanceEdit:9860225] May, Bruce, 2024-01-31 [InstanceEdit:9960863] May, Bruce, 2025-07-17 [InstanceEdit:9983377] May, Bruce, 2026-02-23 [InstanceEdit:9985658] May, Bruce, 2026-03-23
name	Sirt1 binds Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene
output	[Complex:9859940] Sirt1:Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene [nucleoplasm] [Mus musculus]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9859997] R-MMU-9859951.1
structureModified	[InstanceEdit:9960863] May, Bruce, 2025-07-17
summation	[Summation:9860214] Bmal1:Clock binds three E boxes in the promoter and an E box...
(inferredFrom)	[Reaction:9859928] SIRT1 binds p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [Homo sapiens] [Reaction:9961783] SIRT1 binds p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:SIRT1 gene [Homo sapiens]
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No pathways have been reviewed or authored by Sirt1 binds Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene (9859951)