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Details on Person Expression of the CIDEC gene, encoding Lipid transferase CID...
| Class:Id | Summation:9859133 |
|---|---|
| _displayName | Expression of the CIDEC gene, encoding Lipid transferase CID... |
| _timestamp | 2025-11-06 15:57:08 |
| created | [InstanceEdit:9859132] Orlic-Milacic, Marija, 2024-01-15 |
| literatureReference | [LiteratureReference:9859610] Growth hormone controls lipolysis by regulation of FSP27 expression [LiteratureReference:9858073] H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development [LiteratureReference:9859629] Transcriptional activation of Cidec by PPARgamma2 in adipocyte [LiteratureReference:9842041] Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARĪ³2 [LiteratureReference:9858985] Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis |
| modified | [InstanceEdit:9859584] Orlic-Milacic, Marija, 2024-01-21 [InstanceEdit:9859622] Orlic-Milacic, Marija, 2024-01-22 [InstanceEdit:9859634] Orlic-Milacic, Marija, 2024-01-23 [InstanceEdit:9907180] Orlic-Milacic, Marija, 2024-04-04 [InstanceEdit:9907275] Orlic-Milacic, Marija, 2024-04-05 [InstanceEdit:9907286] Orlic-Milacic, Marija, 2024-04-05 [InstanceEdit:9907518] Orlic-Milacic, Marija, 2024-04-11 [InstanceEdit:9907535] Orlic-Milacic, Marija, 2024-04-12 [InstanceEdit:9971031] Orlic-Milacic, Marija, 2025-11-04 [InstanceEdit:9971478] Orlic-Milacic, Marija, 2025-11-06 |
| text | Expression of the CIDEC gene, encoding Lipid transferase CIDEC (also known as Fat-specific protein FSP27 homolog) that is specifically expressed in white adipocytes where it mediates fusion of lipid droplets into a single lipid droplet, is positively regulated in fat tissue by the PPARG:RXRA heterodimer and KMT2C (MLL3)/KMT2D (MLL4) histone methyltransferase complexes. After the differentiation of mouse adipocytes, the expression pattern of Cidec is similar to that of Pparg2 (Kim et al. 2008). The level of Cidec mRNA in mouse adipocytes increases in the presence of PPARG agonists (Kim et al. 2008). By reporter assay, Pparg2 activates transcription from the mouse Cidec gene promoter (Kim et al. 2008). Expression of human CIDEC gene reporter construct is positively regulated by exogenously expressed mouse Pparg and Rxra (Sharma et al. 2018). In contrast, growth hormone (GH)-induced phosphorylation of Pparg and its translocation from the nucleus in mouse white preadipocyte line 3T3-L1 lead to reduced Cidec expression (Sharma et al. 2018). Expression of the Cidec gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information). RNA Pol II occupancy at the mouse Cidec gene promoter is increased in response to PPARG agonists (Nielsen et al. 2008). Based on a mouse model of hepatic steatosis, expression of the Cidec gene is directly stimulated by Pparg2 and the Mll4 complex, but negatively regulated by imatinib, an Abl1 kinase inhibitor that disrupts the Abl1-mediated association between Pparg2 and the Mll4 complex (Kim et al. 2016). |
| (summation) | [BlackBoxEvent:9851534] CIDEC gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex [Homo sapiens] |
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No pathways have been reviewed or authored by Expression of the CIDEC gene, encoding Lipid transferase CID... (9859133)
