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Details on Person TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol

Class:Id	Reaction:9858800
_displayName	TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol
_doRelease	TRUE
_timestamp	2024-07-16 10:31:26
authored	[InstanceEdit:9858813] May, Bruce, 2024-01-14
catalystActivity	[CatalystActivity:9858793] calcium channel activity of TRPV4 tetramer:CALM1:Ca2+ [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9858809] May, Bruce, 2024-01-14
edited	[InstanceEdit:9858813] May, Bruce, 2024-01-14
inferredFrom	[Reaction:9858823] TRPV4 tetramer transports calcium ions (Ca2+) from the extracellular region to the cytosol [Bos taurus] [Reaction:9858790] Trpv4 tetramer transports calcium ions (Ca2+) from the extracellular region to the cytosol [Mus musculus]
input	[SimpleEntity:74112] Ca2+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9863387] Mammalian TRP ion channels are insensitive to membrane stretch [LiteratureReference:9863418] Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress [LiteratureReference:9863414] Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site [LiteratureReference:9865675] Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4
modified	[InstanceEdit:9862182] May, Bruce, 2024-02-23 [InstanceEdit:9863444] May, Bruce, 2024-02-29 [InstanceEdit:9865678] May, Bruce, 2024-03-17 [InstanceEdit:9866199] May, Bruce, 2024-03-23 [InstanceEdit:9915812] May, Bruce, 2024-07-16
name	TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol
output	[SimpleEntity:74016] Ca2+ [cytosol]
precedingEvent	[Reaction:9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) [Homo sapiens] [Reaction:74448] Calcium binds calmodulin [Homo sapiens]
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9858838] R-HSA-9858800.1
summation	[Summation:9862148] TRPV4 channels transport calcium ions across the plasma memb...
(hasEvent)	[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)	[Reaction:74448] Calcium binds calmodulin [Homo sapiens] [Reaction:9855161] Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region [Homo sapiens] [BlackBoxEvent:9858803] MMP14 translocates from the Golgi membrane to the plasma membrane [Homo sapiens] [BlackBoxEvent:9860796] Phosphorylation of PDPK1 on serine-241 [Homo sapiens] [BlackBoxEvent:9861331] Secretion of ADM (Adrenomedullin) [Homo sapiens] [Reaction:9861511] Ca2+ activates Calpain2 (m-Calpain) [Homo sapiens]
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No pathways have been reviewed or authored by TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol (9858800)