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Details on Person LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT

Class:Id	Reaction:9858752
_displayName	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT
_doRelease	TRUE
_timestamp	2024-03-01 10:16:52
authored	[InstanceEdit:9859176] Stephan, Ralf, 2024-01-16
catalystActivity	[CatalystActivity:6792625] lipoyltransferase activity of LIPT1 [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9858750] Stephan, Ralf, 2024-01-14
edited	[InstanceEdit:9859570] Stephan, Ralf, 2024-01-21
input	[EntityWithAccessionedSequence:6793611] Lipo-K107-GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6793611] Lipo-K107-GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6792585] DLAT [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9859177] D'Eustachio, Peter, 2024-01-16
isChimeric	FALSE
literatureReference	[LiteratureReference:6792622] Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene [LiteratureReference:6792624] Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase [LiteratureReference:6797535] Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes [LiteratureReference:9857803] Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes [LiteratureReference:9857798] Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
modified	[InstanceEdit:9859176] Stephan, Ralf, 2024-01-16 [InstanceEdit:9859179] Stephan, Ralf, 2024-01-16 [InstanceEdit:9859570] Stephan, Ralf, 2024-01-21 [InstanceEdit:9863111] Stephan, Ralf, 2024-02-27 [InstanceEdit:9863536] Stephan, Ralf, 2024-03-01
name	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT
output	[EntityWithAccessionedSequence:5693951] GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:5693951] GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:69969] Lipo-K259-DLAT [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:6793591] LIAS synthesizes lipoyl-GCSH [Homo sapiens] [Reaction:6793590] LIPT2 transfers octanoyl group to GCSH [Homo sapiens] [Reaction:8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9861443] Hill, David P, 2024-02-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9858753] R-HSA-9858752.1
summation	[Summation:9858751] Mitochondrial lipoyltransferase 1 (LIPT1) catalyses the tran...
(hasEvent)	[Pathway:9857492] Protein lipoylation [Homo sapiens]
(precedingEvent)	[Reaction:6793590] LIPT2 transfers octanoyl group to GCSH [Homo sapiens]
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