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Details on Person MITF-M-dependent expression of CDKN2A gene product 16INK4A

Class:Id	BlackBoxEvent:9858651
_displayName	MITF-M-dependent expression of CDKN2A gene product 16INK4A
_doRelease	TRUE
_timestamp	2024-11-08 15:57:57
authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9858637] Rothfels, Karen, 2024-01-13
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
input	[EntityWithAccessionedSequence:3200017] CDKN2A gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9857154] MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A [LiteratureReference:9858634] p16(Ink4a) in melanocyte senescence and differentiation [LiteratureReference:9859430] Germline p16 mutations in familial melanoma [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9858510] Pro-survival role of MITF in melanoma [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9857138] Cancer stem cells versus phenotype-switching in melanoma
modified	[InstanceEdit:9859473] Rothfels, Karen, 2024-01-19 [InstanceEdit:9863248] Rothfels, Karen, 2024-02-28 [InstanceEdit:9863252] Rothfels, Karen, 2024-02-28 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent expression of CDKN2A gene product 16INK4A
output	[EntityWithAccessionedSequence:182578] p16INK4A [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9858652] MITF-M dimer binds the CDKN2A gene [Homo sapiens] [Reaction:9857375] MITF dimerizes [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9858624] Positive gene expression regulation by 'MITF-M dimer:CDKN2A gene [nucleoplasm]'
regulationReference	[RegulationReference:9858649] Positive gene expression regulation by 'MITF-M dimer:CDKN2A gene [nucleoplasm]' MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9858657] R-HSA-9858651.3
summation	[Summation:9858607] CDKN2A encodes the cyclin-dependent kinase inhibitor p16INK4...
(hasEvent)	[Pathway:9825892] Regulation of MITF-M-dependent genes involved in cell cycle and proliferation [Homo sapiens]
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