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Details on Person HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter

Class:Id	Reaction:9858647
_displayName	HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter
_doRelease	TRUE
_timestamp	2024-11-08 15:54:22
authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9858637] Rothfels, Karen, 2024-01-13
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
input	[Complex:9858620] TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205021] HDAC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:351657] SIN3A [nucleoplasm] [Homo sapiens] [Complex:9825721] HINT1 dimer [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9825671] The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
modified	[InstanceEdit:9858742] Rothfels, Karen, 2024-01-14 [InstanceEdit:9863246] Rothfels, Karen, 2024-02-28 [InstanceEdit:9907153] Rothfels, Karen, 2024-04-04 [InstanceEdit:9909022] Rothfels, Karen, 2024-04-25 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9927678] Rothfels, Karen, 2024-11-08
name	HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter
output	[Complex:9858619] HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9858646] TCF/LEF:CTNNB1 binds the CCND1 gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewed	[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9858653] R-HSA-9858647.2
structureModified	[InstanceEdit:9858742] Rothfels, Karen, 2024-01-14
summation	[Summation:9858604] CTNNB1-dependent expression of the G1/S cyclin CCND1 is repr...
(hasEvent)	[Pathway:9825892] Regulation of MITF-M-dependent genes involved in cell cycle and proliferation [Homo sapiens]
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No pathways have been reviewed or authored by HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (9858647)