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Details on Person TCF/LEF:CTNNB1 binds the CCND1 gene

Class:IdReaction:9858646
_displayNameTCF/LEF:CTNNB1 binds the CCND1 gene
_doReleaseTRUE
_timestamp2024-11-08 15:58:48
authored[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9858637] Rothfels, Karen, 2024-01-13
edited[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
input[Complex:4411394] TCF/LEF:CTNNB1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8853953] CCND1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimericFALSE
literatureReference[LiteratureReference:9825671] The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
modified[InstanceEdit:9863246] Rothfels, Karen, 2024-02-28
[InstanceEdit:9907153] Rothfels, Karen, 2024-04-04
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
nameTCF/LEF:CTNNB1 binds the CCND1 gene
output[Complex:9858620] TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeGeneExpressionRegulation:9858618] Negative gene expression regulation by 'HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm]'
regulationReference[RegulationReference:9858638] Negative gene expression regulation by 'HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm]' The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
releaseDate2024-03-27
reviewed[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26
[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9858662] R-HSA-9858646.3
structureModified[InstanceEdit:9907153] Rothfels, Karen, 2024-04-04
summation[Summation:9858601] CCND1 expression in melanoma cells depends in part on the bi...
(hasEvent)[Pathway:9825892] Regulation of MITF-M-dependent genes involved in cell cycle and proliferation [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9858645] MITF-M and CTNNB1-dependent CCND1 expression [Homo sapiens]
[Reaction:9858647] HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter [Homo sapiens]
(updatedInstance)[_UpdateTracker:9911103] Update Tracker - [Reaction:9858646] TCF/LEF:CTNNB1 binds the CCND1 gene - v89:[addRegulator]
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