Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Expression of the G1/S cyclin CCND1 is activated by MITF, an...
| Class:Id | Summation:9858605 |
|---|---|
| _displayName | Expression of the G1/S cyclin CCND1 is activated by MITF, an... |
| _timestamp | 2024-01-19 17:56:21 |
| created | [InstanceEdit:9858610] Rothfels, Karen, 2024-01-13 |
| modified | [InstanceEdit:9859473] Rothfels, Karen, 2024-01-19 |
| text | Expression of the G1/S cyclin CCND1 is activated by MITF, and MITF binds to an E-box element in its promoter as assessed by ChIP. Consistent with this, expression of a CCND1 reporter is abrogated upon siRNA-mediated knockdown of MITF (Strub et al, 2011). CCND1 has additionally been identified as a direct target of beta-catenin-mediated upregulation in melanoma cells, and this activity appears to be repressible by a complex of HINT1, SIN3A and HDAC1 (Genovese et al, 2013). MITF- and beta-catenin-dependent CCND1 expression in melanoma cells contributes to the proliferative phenotype of cells expressing intermediate levels of MITF (reviewed in Goding and Arnheiter, 2019). |
| (summation) | [Reaction:9858650] MITF-M dimer binds the CCND1 gene [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Expression of the G1/S cyclin CCND1 is activated by MITF, an... (9858605)
